Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Physiological importance of SR-BI in the in vivo metabolism of human HDL and LDL in male and female mice.

Journal of lipid research - 1 Apr 2005

Brodeur Mathieu R, Luangrath Vilayphone, Bourret Geneviève, Falstrault Louise, Brissette Louise

Abstract excerpt

The physiological role of murine scavenger receptor class B type I (SR-BI) was evaluated by in vivo clearances of human HDL3 and LDL in normal and SR-BI knockout (KO) mice. In normal mice, cholesteryl esters (CEs) were removed faster than proteins, indicating a selective uptake process from both HDL3 and LDL. SR-BI KO mice showed 80% losses of HDL-CE selective uptake and the complete loss of LDL-CE selective...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholesterol Esters
Share to Lipoproteins, HDL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipoproteins, LDL

Share to Receptors, LDL

Share to Receptors, Lipoprotein

Share to Scavenger Receptors, Class B

Share to Sex Characteristics

Source

Identifiers

PMID: 15654132
DOI: 10.1194/jlr.M400165-JLR200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Physiological importance of SR-BI in the in vivo metabolism of human HDL and LDL in male and female mice.PMID 15654132Read ↗

Decreased selective uptake of high density lipoprotein cholesteryl esters in apolipoprotein E knock-out mice.Semantic proximity Read ↗

Influence of the HDL Receptor SR-BI on Lipoprotein Metabolism and AtherosclerosisSemantic proximity Read ↗

A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism.Semantic proximity Read ↗

Functional genomics of the human high-density lipoprotein receptor scavenger receptor BI: an old dog with new tricks.Semantic proximity Read ↗

Mouse CD36 Has Opposite Effects on LDL and Oxidized LDL Metabolism In VivoSemantic proximity Read ↗

Knockdown expression and hepatic deficiency reveal an atheroprotective role for SR-BI in liver and peripheral tissues.Semantic proximity Read ↗

Scavenger receptor class B type I protein as an independent predictor of high-density lipoprotein cholesterol levels in subjects with hyperalphalipoproteinemia.Semantic proximity Read ↗

High Free Cholesterol Bioavailability Drives the Tissue Pathologies in Scarb1-/- Mice.Semantic proximity Read ↗

Genetic studies in mice and humans reveal new physiological roles for the high-density lipoprotein receptor scavenger receptor class B type I.Semantic proximity Read ↗

Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL.Semantic proximity Read ↗

SR-BI mediates cholesterol efflux via its interactions with lipid-bound ApoE. Structural mutations in SR-BI diminish cholesterol efflux.Semantic proximity Read ↗

Increased apolipoprotein M induced by lack of scavenger receptor BI is not activated via HDL-mediated cholesterol uptake in hepatocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.