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Article

SCARB1 Gene Variants Are Associated With the Phenotype of Combined High High-Density Lipoprotein Cholesterol and High Lipoprotein (a).

Circulation. Cardiovascular genetics - 1 Oct 2016

Yang Xiaoping, Sethi Amar, Yanek Lisa R, Knapper Cathy, Nordestgaard Børge G, Tybjærg-Hansen Anne, Becker Diane M, Mathias Rasika A, Remaley Alan T, Becker Lewis C

Abstract excerpt

BACKGROUND: SR-B1 (scavenger receptor class B type 1), encoded by the gene SCARB1, is a lipoprotein receptor that binds both high-density lipoprotein (HDL) and low-density lipoprotein. We reported that SR-B1 is also a receptor for lipoprotein (a) (Lp(a)), mediating cellular uptake of Lp(a) in vitro and promoting clearance of Lp(a) in vivo. Although genetic variants in SCARB1 are associated with variations in HDL...

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Source

Identifiers

PMID: 27651445
DOI: 10.1161/CIRCGENETICS.116.001402

Genes

SCARB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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