Article
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.
Science (New York, N.Y.) - 11 Mar 2016
Zanoni Paolo, Khetarpal Sumeet A, Larach Daniel B, Hancock-Cerutti William F, Millar John S, Cuchel Marina, DerOhannessian Stephanie, Kontush Anatol, Surendran Praveen, Saleheen Danish, Trompet Stella, Jukema J Wouter, De Craen Anton, Deloukas Panos, Sattar Naveed, Ford Ian, Packard Chris, Majumder Abdullah al Shafi, Alam Dewan S, Di Angelantonio Emanuele, Abecasis Goncalo, Chowdhury Rajiv, Erdmann Jeanette, Nordestgaard Børge G, Nielsen Sune F, Tybjærg-Hansen Anne, Schmidt Ruth Frikke, Kuulasmaa Kari, Liu Dajiang J, Perola Markus, Blankenberg Stefan, Salomaa Veikko, Männistö Satu, Amouyel Philippe, Arveiler Dominique, Ferrieres Jean, Müller-Nurasyid Martina, Ferrario Marco, Kee Frank, Willer Cristen J, Samani Nilesh, Schunkert Heribert, Butterworth Adam S, Howson Joanna M M, Peloso Gina M, Stitziel Nathan O, Danesh John, Kathiresan Sekar, Rader Daniel J
Abstract excerpt
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL) cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower risk of coronary heart disease (CHD). Mice that have depleted Scarb1 (SR-BI knockout mice) have markedly elevated HDL-C levels but, paradoxically, increased atherosclerosis. The impact of SR-BI on HDL metabolism and CHD risk in humans...
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