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Article

Role of RNA Binding Proteins with prion-like domains in muscle and neuromuscular diseases

9 Mar 2020

Abstract excerpt

A number of neuromuscular and muscular diseases, including amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA) and several myopathies, are associated to mutations in related RNA-binding proteins (RBPs), including TDP-43, FUS, MATR3 or hnRNPA1/B2. These proteins harbor similar modular primary sequence with RNA binding motifs and low complexity domains, that enables them to phase separate and create...

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PMID: 32292882
DOI: 10.15698/cst2020.04.217

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