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Article

Transcriptional downregulation of FAM3C/ILEI in the Alzheimer’s brain

2 Aug 2021

Abstract excerpt

Amyloid-β (Aβ) accumulation in the brain triggers the pathogenic cascade for Alzheimer's disease (AD) development. The secretory protein FAM3C (also named ILEI) is a candidate for an endogenous suppressor of Aβ production. In this study, we found that FAM3C expression was transcriptionally downregulated in the AD brain. To determine the transcriptional mechanism of the human FAM3C gene, we delineated the minimal...

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PMID: 34378027
DOI: 10.1093/hmg/ddab226

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