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Article

Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling.

Blood - 1 Oct 2007

Zhu Jieqing, Carman Christopher V, Kim Minsoo, Shimaoka Motomu, Springer Timothy A, Luo Bing-Hao

Abstract excerpt

Adhesion to extracellular ligands through integrins regulates cell shape, migration, growth, and survival. How integrins transmit signals in the outside-to-in direction remains unknown. Whereas in resting integrins the alpha and beta subunit transmembrane domains are associated, ligand binding promotes dissociation and separation of these domains. Here we address whether such separation is required for outside-in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17615290
DOI: 10.1182/blood-2007-03-080077
PMCID: PMC1988953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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