Article
Intra-strain and inter-strain heterogeneity shape phage-host interactions and phenotypic adaptation in Pseudomonas aeruginosa.
Applied and environmental microbiology - 22 Apr 2026
Sui Bingrui, Li Xiaoyu, Wang Lili, Xu Yongping, Hou Yumin, Khan Muhammad Saleem Iqbal, Li Na, Tan Demeng
Abstract excerpt
The efficacy of phage therapy relies on a precise understanding of phage-host interactions, particularly how phages recognize bacterial surface receptors and how these interactions shape host adaptation. In Pseudomonas aeruginosa, the O-antigen of lipopolysaccharide (LPS) is a common but incompletely characterized determinant of phage susceptibility. Here, we used an O-antigen-specific lytic podophage, phipa9, to...
Topics
- Pseudomonas aeruginosa
- O Antigens
- Pseudomonas Phages
- Phenotype
- Animals