Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Berberine alleviates DSS-induced colitis by modulating macrophage phenotype via PPAR-γ/ mTOR/HIF-1α signaling pathway.

Journal of ethnopharmacology - 10 May 2026

He Long, Zhong Zhuotai, Liu Fengbin, Wen Shuting

Abstract excerpt

ETHNOPHARMACOLOGICAL RELEVANCE: Berberine (BBR), an isoquinoline alkaloid derived from Chinese herbal drugs of Coptis chinensis Franch. and Phellodendron chinense C.K. Schneid., has been traditionally extensively utilized in treating acute or chronic diarrhea and distension. In modern medical practice, BBR has also been developed to remit diarrhea of ulcerative colitis (UC). However, the potential mechanism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colitis
Share to Colon
Share to Dextran Sulfate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Macrophages

Share to PPAR gamma

Share to RAW 264.7 Cells

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 41679358
DOI: 10.1016/j.jep.2026.121350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Berberine alleviates DSS-induced colitis by modulating macrophage phenotype via PPAR-γ/ mTOR/HIF-1α signaling pathway.PMID 41679358Read ↗

Luteolin modulates macrophage phenotypic switching via the AMPK-PPARγ pathway to alleviate ulcerative colitis in mice.Semantic proximity Read ↗

Jiedu Xiaozheng Yin Inhibits the Progression of Colitis Associated Colorectal Cancer by Stimulating Macrophage Polarization Towards an M1 Phenotype via the TLR4 Pathway.Semantic proximity Read ↗

Caffeine Has Different Immunomodulatory Effect on the Cytokine Expression and NLRP3 Inflammasome Function in Various Human Macrophage Subpopulations.Semantic proximity Read ↗

Chemical profile of Xian-He-Cao-Chang-Yan formula and its effects on ulcerative colitis.Semantic proximity Read ↗

Ginsenoside Rg1 Ameliorated Colitis by Regulating the Homeostasis of M1/M2 Macrophage Polarization and Intestinal FloraSemantic proximity Read ↗

Phytochemical Modulation of Astrocyte A1/A2 Polarization and Hepcidin-Associated Iron Dysregulation in LPS-Driven NeuroinflammationSemantic proximity Read ↗

Microbial metabolite butyrate facilitates M2 macrophage polarization and function.Semantic proximity Read ↗

The anti-inflammatory mechanism of berberine on lipopolysaccharide-induced IEC-18 models based on comparative transcriptomicsSemantic proximity Read ↗

Chlorogenic acid inhibits glioblastoma growth through repolarizating macrophage from M2 to M1 phenotype.Semantic proximity Read ↗

Salvianolic acid B inhibits RAW264.7 cell polarization towards the M1 phenotype by inhibiting NF-κB and Akt/mTOR pathway activation.Semantic proximity Read ↗

The critical role of P2XR/PGC-1α signalling pathway in hypoxia-mediated pyroptosis and M1/M2 phenotypic differentiation of mouse microglia.Semantic proximity Read ↗

Luteolin Alters Macrophage Polarization to Inhibit Inflammation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.