Article

Modulation of IRAK4 as a Therapeutic Strategy Against Monosodium Urate- and Xanthine-Induced Inflammation in Macrophages and HepG2 Cells

2025-07-16

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Interleukin-1 receptor-associated kinase 4 (IRAK4) is a pivotal mediator of toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling, critically involved in innate immune activation and pro-inflammatory cytokine production. Dysregulated IRAK4 activity contributes to chronic inflammation in both immune and non-immune cells. In this study, we evaluated...

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Anti-Inflammatory Agents
Inflammasomes
Macrophages
MicroRNAs
NF-kappa B
NLR Family, Pyrin Domain-Containing 3 Protein
STAT3 Transcription Factor
Uric Acid

Identifiers and source

Literature Corpus work: b3b0e34b-06df-5708-ac18-0c140a3e01d0
DOI: 10.21203/rs.3.rs-6908346/v1

Open publication