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Article

Cyclic AMP Regulates Key Features of Macrophages via PKA: Recruitment, Reprogramming and Efferocytosis.

Cells - 6 Jan 2020

Negreiros-Lima Graziele L, Lima Kátia M, Moreira Isabella Z, Jardim Bruna Lorrayne O, Vago Juliana P, Galvão Izabela, Teixeira Lívia Cristina R, Pinho Vanessa, Teixeira Mauro M, Sugimoto Michelle A, Sousa Lirlândia P

Abstract excerpt

Macrophages are central to inflammation resolution, an active process aimed at restoring tissue homeostasis following an inflammatory response. Here, the effects of db-cAMP on macrophage phenotype and function were investigated. Injection of db-cAMP into the pleural cavity of mice induced monocytes recruitment in a manner dependent on PKA and CCR2/CCL2 pathways. Furthermore, db-cAMP promoted reprogramming of...

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Identifiers

PMID: 31935860
DOI: 10.3390/cells9010128
PMCID: PMC7017228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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