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Article

Luteolin modulates macrophage phenotypic switching via the AMPK-PPARγ pathway to alleviate ulcerative colitis in mice.

Journal of ethnopharmacology - 13 Jan 2025

Yang Shuai, Duan Hongwei, Zeng Jianlin, Yan Zhenxing, Niu Tian, Ma Xiaofei, Zhang Yong, Hu Junjie, Zhang Lihong, Zhao Xingxu

Abstract excerpt

ETHNOPHARMACOLOGICAL RELEVANCE: Lonicerae japonicae flos (LJF), the dried flower bud or newly bloomed flower of Lonicera japonica Thunb., is widely used in Traditional Chinese medicine (TCM), exhibiting anti-inflammatory and immune-enhancing properties. Luteolin (Lut) is a major bioactive component of LJF, demonstrating a regulatory role in immune disorders. However, the specific role of Lut in regulating...

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PMID: 39603400
DOI: 10.1016/j.jep.2024.119157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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