CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors.

doi:10.1016/j.nbd.2021.105473

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Article

CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors.

Neurobiology of disease - 1 Oct 2021

Crittenden Jill R, Zhai Shenyu, Sauvage Magdalena, Kitsukawa Takashi, Burguière Eric, Thomsen Morgane, Zhang Hui, Costa Cinzia, Martella Giuseppina, Ghiglieri Veronica, Picconi Barbara, Pescatore Karen A, Unterwald Ellen M, Jackson Walker S, Housman David E, Caine S Barak, Sulzer David, Calabresi Paolo, Smith Anne C, Surmeier D James, Graybiel Ann M

Abstract excerpt

CalDAG-GEFI (CDGI) is a protein highly enriched in the striatum, particularly in the principal spiny projection neurons (SPNs). CDGI is strongly down-regulated in two hyperkinetic conditions related to striatal dysfunction: Huntington's disease and levodopa-induced dyskinesia in Parkinson's disease. We demonstrate that genetic deletion of CDGI in mice disrupts dendritic, but not somatic, M1 muscarinic receptors...

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PMID: 34371144
DOI: 10.1016/j.nbd.2021.105473
PMCID: PMC8486000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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