Article

Characterization of mice with cell type-specific <i>Gnal</i> loss of function provides insights on <i>GNAL</i> -linked dystonia

2025-07-03

Abstract excerpt

Isolated dystonia can be caused by loss-of-function mutations in the GNAL gene (DYT-GNAL). This gene encodes the α olf heterotrimeric G protein subunit, which, together with β 2 γ 7 subunits, mediates the stimulatory coupling of dopamine D1 and adenosine A2A receptors to adenylyl-cyclase. These receptors are expressed in distinct striatal projection neurons (SPNs) with complementary functions on motor behavior...

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Literature Corpus work: 9c5338cf-5cb4-55ae-a4b2-b79fecbbd7ff
DOI: 10.1101/2025.07.02.662743

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