Article
CYP2D6 inhibition by selective serotonin reuptake inhibitors: analysis of achievable steady-state plasma concentrations and the effect of ultrarapid metabolism at CYP2D6.
Pharmacotherapy - 1 Aug 2002
Lam Y W Francis, Gaedigk Andrea, Ereshefsky Larry, Alfaro Cara L, Simpson Joe
Abstract excerpt
STUDY OBJECTIVE: To assess the correlation between plasma concentrations of four commonly administered selective serotonin reuptake inhibitors (SSRIs) and the magnitude of cytochrome P450 (CYP) 2D6 inhibition. DESIGN: Prospective analysis. SETTING: University-affiliated research laboratory. PATIENTS: Thirty-two healthy, drug-free volunteers. INTERVENTION: Subjects were randomized to four groups and received daily...
Topics
- Cyclooxygenase Inhibitors
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 CYP2D6 Inhibitors
- Dextromethorphan
- Dextrorphan
- Fluoxetine
- Fluvoxamine
- Genotype
- Humans
- Paroxetine