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Article

M2a macrophages facilitate resolution of chemically-induced colitis in TLR4-SNP mice.

mBio - 31 Oct 2023

Vlk Alexandra M, Prantner Daniel, Shirey Kari Ann, Perkins Darren J, Buzza Marguerite S, Thumbigere-Math Vivek, Keegan Achsah D, Vogel Stefanie N

Abstract excerpt

IMPORTANCE: Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, impacts millions of individuals worldwide and severely impairs the quality of life for patients. Dysregulation of innate immune signaling pathways reduces barrier function and exacerbates disease progression. Macrophage (Mφ) signaling pathways are potential targets for IBD therapies. While multiple treatments are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37768050
DOI: 10.1128/mbio.01208-23
PMCID: PMC10653841

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