An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes.

doi:10.1172/JCI86282

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Article

An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes.

The Journal of clinical investigation - 1 Jun 2017

Yan Jie, Hedl Matija, Abraham Clara

Abstract excerpt

Inflammatory bowel disease (IBD) is characterized by dysregulation in both cytokines and responses to intestinal microbes, and proper regulation of pattern recognition receptor (PRR) signaling is critical for intestinal immune homeostasis. Altered functions for the IBD risk locus containing rs7554511, which encompasses the C1orf106 gene (recently named INAVA), and roles for the protein encoded by the INAVA gene...

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Identifiers

PMID: 28436939
DOI: 10.1172/JCI86282
PMCID: PMC5451247

Genes

INAVA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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