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Association analysis and polygenic risk score evaluation of 38 GWAS-identified Loci in a Chinese population with Parkinson's disease.

Neuroscience letters - 25 Sept 2021

Zheng Ran, Qiao Song, Chen Ying, Jin Chongyao, Fang Yi, Lin Zhihao, Xue Naijia, Yan Yiqun, Gu Luyan, Gao Ting, Tian Jun, Yan Yaping, Yin Xinzhen, Pu Jiali, Zhang Baorong

Abstract excerpt

OBJECTIVE: Recently, a meta-analysis of genome-wide association studies (GWASs) has identified 38 novel independent loci associated with risk of Parkinson's disease (PD) in European populations. We sought to investigate whether these genetic susceptibility variants could be replicated in the Chinese Han population. METHODS: We genotyped 38 independent loci in 495 Chinese sporadic PD patients and 470 unrelated...

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PMID: 34352340
DOI: 10.1016/j.neulet.2021.136150

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