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Article

The CYP2C192 and CYP2C1917 Polymorphisms play a Vital Role in Clopidogrel Responsiveness after Percutaneous Coronary Intervention: A Pharmacogenomics Study.

Basic & clinical pharmacology & toxicology - 1 Jul 2017

Saydam Faruk, Değirmenci İrfan, Birdane Alparslan, Özdemir Mahmut, Ulus Taner, Özbayer Cansu, Çolak Ertuğrul, Ata Necmi, Güneş Hasan Veysi

Abstract excerpt

Clopidogrel inhibits platelet activation and aggregation by blocking the P2Y12 receptor. Dual antiplatelet therapy with clopidogrel and aspirin is recommended treatment by current guidelines for patients undergoing percutaneous interventions. Recurrent ischaemic cardiac events after this treatment showed lack of clopidogrel responsiveness. We aimed to investigate the most noticeable variants in the genes involved...

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Source

Identifiers

PMID: 28135763
DOI: 10.1111/bcpt.12763

Genes

ABCB1
ITGB3
PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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