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Article

Paraoxonase-1 Q192R polymorphism and antiplatelet effects of clopidogrel in patients undergoing elective coronary stent placement.

Circulation. Cardiovascular genetics - 1 Aug 2011

Trenk Dietmar, Hochholzer Willibald, Fromm Martin F, Zolk Oliver, Valina Christian M, Stratz Christian, Neumann Franz-Josef

Abstract excerpt

BACKGROUND: Recently published data indicate that the paraoxonase-1 (PON1) Q192R genotype-and not as previously shown activity of cytochrome P450 (CYP) 2C19-is the major determinant of metabolic bioactivation of clopidogrel and thereby variability of antiplatelet effect of clopidogrel. We sought to investigate whether the PON1 Q192R gene polymorphism affects platelet reactivity in patients undergoing elective...

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Source

Identifiers

PMID: 21685174
DOI: 10.1161/CIRCGENETICS.111.960112

Genes

PON1

Variants

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Paraoxonase-1 Q192R polymorphism and antiplatelet effects of clopidogrel in patients undergoing elective coronary stent placement.PMID 21685174Read ↗

No association of paraoxonase-1 Q192R genotypes with platelet response to clopidogrel and risk of stent thrombosis after coronary stenting.Semantic proximity Read ↗

PON1 Q192R is associated with high platelet reactivity with clopidogrel in patients undergoing elective neurointervention: A prospective single-center cohort study.Semantic proximity Read ↗

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PON1 Q192R genotype influences clopidogrel responsiveness by relative platelet inhibition instead of on-treatment platelet reactivity.Semantic proximity Read ↗

The impact of cytochrome 450 and Paraoxonase polymorphisms on clopidogrel resistance and major adverse cardiac events in coronary heart disease patients after percutaneous coronary intervention.Semantic proximity Read ↗

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Besides CYP2C19*2, the variant allele CYP2C9*3 is associated with higher on-clopidogrel platelet reactivity in patients on dual antiplatelet therapy undergoing elective coronary stent implantation.Semantic proximity Read ↗

CYP2C19 but not PON1 genetic variants influence clopidogrel pharmacokinetics, pharmacodynamics, and clinical efficacy in post-myocardial infarction patients.Semantic proximity Read ↗

Paraoxonase 1 (PON1) gene variants are not associated with clopidogrel response.Semantic proximity Read ↗

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