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Article

No association of paraoxonase-1 Q192R genotypes with platelet response to clopidogrel and risk of stent thrombosis after coronary stenting.

European heart journal - 1 Jul 2011

Sibbing Dirk, Koch Werner, Massberg Steffen, Byrne Robert A, Mehilli Julinda, Schulz Stefanie, Mayer Katharina, Bernlochner Isabell, Schömig Albert, Kastrati Adnan

Abstract excerpt

AIMS: In clopidogrel-treated patients undergoing coronary stenting, high on-treatment platelet reactivity was linked to a higher risk of stent thrombosis (ST). Platelet response to clopidogrel is significantly influenced by genetic factors. Recently published findings showed a highly significant impact of a common polymorphism (Q192R) within the paraoxonase-1 (PON1) gene on clopidogrel treatment efficacy but no...

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Identifiers

PMID: 21527445
DOI: 10.1093/eurheartj/ehr155

Genes

PON1

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No association of paraoxonase-1 Q192R genotypes with platelet response to clopidogrel and risk of stent thrombosis after coronary stenting.PMID 21527445Read ↗

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PON1 Q192R is associated with high platelet reactivity with clopidogrel in patients undergoing elective neurointervention: A prospective single-center cohort study.Semantic proximity Read ↗

PON1 Q192R genotype influences clopidogrel responsiveness by relative platelet inhibition instead of on-treatment platelet reactivity.Semantic proximity Read ↗

Paraoxonase 1 (PON1) gene variants are not associated with clopidogrel response.Semantic proximity Read ↗

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Association between Q192R PON1 genetic polymorphism and major adverse cardiovascular events in patients treated with clopidogrel: an updated meta-analysis.Semantic proximity Read ↗

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