Article
Paraoxonase 1 (PON1) gene variants are not associated with clopidogrel response.
Clinical pharmacology and therapeutics - 1 Oct 2011
Lewis J P, Fisch A S, Ryan K, O'Connell J R, Gibson Q, Mitchell B D, Shen H, Tanner K, Horenstein R B, Pakzy R, Tantry U S, Bliden K P, Gurbel P A, Shuldiner A R
Abstract excerpt
A common functional variant in paraoxonase 1 (PON1), Q192R, was recently reported to be a major determinant of clopidogrel response. This variant was genotyped in 566 participants of the Amish Pharmacogenomics of Anti-Platelet Intervention (PAPI) study and in 227 percutaneous coronary intervention (PCI) patients. Serum paraoxonase activity was measured in a subset of 79 PAPI participants. PON1 Q192R was not...
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