Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defective RNA polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 pathway.

eLife - 7 Sept 2018

Wang Zheng, Wu Catherine, Aslanian Aaron, Yates John R, Hunter Tony

Abstract excerpt

Transcription by RNA polymerase III (Pol III) is an essential cellular process, and mutations in Pol III can cause neurodegenerative disease in humans. However, in contrast to Pol II transcription, which has been extensively studied, the knowledge of how Pol III is regulated is very limited. We report here that in budding yeast, Saccharomyces cerevisiae, Pol III is negatively regulated by the Small Ubiquitin-like...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, Suppressor
Share to Mutant Proteins
Share to RNA Polymerase III

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Small Ubiquitin-Related Modifier Proteins

Share to Sumoylation

Share to Ubiquitin

Share to Ubiquitination

Share to Valosin Containing Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 30192228
DOI: 10.7554/eLife.35447
PMCID: PMC6128692

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defective RNA polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 pathway.PMID 30192228Read ↗

Defective RNA Polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 PathwaySemantic proximity Read ↗

Sumoylation: a regulatory protein modification in health and disease.Semantic proximity Read ↗

Ubc9 sumoylation controls SUMO chain formation and meiotic synapsis in Saccharomyces cerevisiae.Semantic proximity Read ↗

The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B.Semantic proximity Read ↗

RNA Polymerase III Subunit Mutations in Genetic DiseasesSemantic proximity Read ↗

RNA polymerase III transcription as a disease factor.Semantic proximity Read ↗

Sumoylation of the DNA polymerase ε by the Smc5/6 complex contributes to DNA replication.Semantic proximity Read ↗

Coordination of transcription-coupled repair and repair-independent release of stalled RNA polymerase II in response to transcription-blocking lesionsSemantic proximity Read ↗

The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins.Semantic proximity Read ↗

Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast.Semantic proximity Read ↗

Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae.Semantic proximity Read ↗

Genome-wide distribution of yeast RNA polymerase II and its control by Sen1 helicase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.