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Article

PURPL represses autophagic cell death to promote cutaneous melanoma by modulating ULK1 phosphorylation

10 Nov 2021

Abstract excerpt

Uncontrolled overactivation of autophagy may lead to autophagic cell death, suppression of which is a pro-survival strategy for tumors. However, mechanisms involving key regulators in modulating autophagic cell death remain poorly defined. Here, we report a novel long noncoding RNA, p53 upregulated regulator of p53 levels (PURPL), functions as an oncogene to promote cell proliferation, colony formation,...

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PMID: 34759263
DOI: 10.1038/s41419-021-04362-8

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