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Article

LMNA E82K mutation activates FAS and mitochondrial pathways of apoptosis in heart tissue specific transgenic mice.

PloS one - 6 Dec 2010

Lu Dan, Lian Hong, Zhang Xiaojuan, Shao Haitao, Huang Lan, Qin Chuan, Zhang Lianfeng

Abstract excerpt

The lamin A/C (LMNA), nuclear intermediate filament proteins, is a basic component of the nuclear lamina. Mutations in LMNA are associated with a broad range of laminopathies, congenital diseases affecting tissue regeneration and homeostasis. Heart tissue specific transgenic mice of human LMNA E8...

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Source

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Identifiers

PMID: 21151901
DOI: 10.1371/journal.pone.0015167
PMCID: PMC2997782

Genes

LMNA
FAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21151901-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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