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Article

A novel gain-of-function mutation of the proneural IRX1 and IRX2 genes disrupts axis elongation in the Araucana rumpless chicken.

PloS one - 1 Jan 2014

Freese Nowlan H, Lam Brianna A, Staton Meg, Scott Allison, Chapman Susan C

Abstract excerpt

Axis elongation of the vertebrate embryo involves the generation of cell lineages from posterior progenitor populations. We investigated the molecular mechanism governing axis elongation in vertebrates using the Araucana rumpless chicken. Araucana embryos exhibit a defect in axis elongation, failing to form the terminal somites and concomitant free caudal vertebrae, pygostyle, and associated tissues of the tail....

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Source

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Identifiers

PMID: 25372603
DOI: 10.1371/journal.pone.0112364
PMCID: PMC4221472

Genes

IRX1
IRX2
SOX2
TBX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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