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Article

<i>barx1</i> represses joints and promotes cartilage in the craniofacial skeleton

22 May 2013

Abstract excerpt

The evolution of joints, which afford skeletal mobility, was instrumental in vertebrate success. Here, we explore the molecular genetics and cell biology that govern jaw joint development. Genetic manipulation experiments in zebrafish demonstrate that functional loss, or gain, of the homeobox-containing gene barx1 produces gain, or loss, of joints, respectively. Ectopic joints in barx1 mutant animals are present...

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PMID: 23698351
DOI: 10.1242/dev.090639

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