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Article

ELAC2/RNaseZ-linked cardiac hypertrophy in Drosophila melanogaster.

Disease models & mechanisms - 1 Aug 2021

Migunova Ekaterina, Theophilopoulos Joanna, Mercadante Marisa, Men Jing, Zhou Chao, Dubrovsky Edward B

Abstract excerpt

A severe form of infantile cardiomyopathy (CM) has been linked to mutations in ELAC2, a highly conserved human gene. It encodes Zinc phosphodiesterase ELAC protein 2 (ELAC2), which plays an essential role in the production of mature tRNAs. To establish a causal connection between ELAC2 variants and CM, here we used the Drosophila melanogaster model organism, which carries the ELAC2 homolog RNaseZ. Even though...

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Identifiers

PMID: 34338278
DOI: 10.1242/dmm.048931
PMCID: PMC8419712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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