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<i>Drosophila</i> ryanodine receptor gene triggers functional and developmental muscle properties and could be used to assess the impact of human <i>RYR1</i> mutations

2025-11-08

Abstract excerpt

<h4>ABSTRACT</h4> The ryanodine receptor (RYR) genes encode evolutionarily conserved calcium release channels involved in a wide range of calcium-dependent biological processes. Here we show that the sole Drosophila RYR gene ( dRyR ) functions in differentiated somatic and cardiac muscle as well as in developing embryonic myotubes. In the larval body wall muscles, dRyR protein localizes at the SR membranes and...

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Literature Corpus work
37e3e488-47f2-5124-a0f8-dc90166e7d36
DOI
10.1101/2025.11.06.686948
Open publication

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<i>Drosophila</i> ryanodine receptor gene triggers functional and developmental muscle properties and could be used to assess the impact of human <i>RYR1</i> mutationsDOI 10.1101/2025.11.06.686948
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