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Article

Drosophila Models Reveal Properties of Mutant Lamins That Give Rise to Distinct Diseases.

Cells - 12 Apr 2023

Walker Sydney G, Langland Christopher J, Viles Jill, Hecker Laura A, Wallrath Lori L

Abstract excerpt

Mutations in the LMNA gene cause a collection of diseases known as laminopathies, including muscular dystrophies, lipodystrophies, and early-onset aging syndromes. The LMNA gene encodes A-type lamins, lamins A/C, intermediate filaments that form a meshwork underlying the inner nuclear membrane. Lamins have a conserved domain structure consisting of a head, coiled-coil rod, and C-terminal tail domain possessing an...

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Identifiers

PMID: 37190051
DOI: 10.3390/cells12081142
PMCID: PMC10136830

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