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Article

Novel role of reactive oxygen species-activated Trp melastatin channel-2 in mediating angiogenesis and postischemic neovascularization.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2015

Mittal Manish, Urao Norifumi, Hecquet Claudie M, Zhang Min, Sudhahar Varadarajan, Gao Xiao-Pei, Komarova Yulia, Ushio-Fukai Masuko, Malik Asrar B

Abstract excerpt

OBJECTIVE: Transient receptor potential melastatin-2 (TRPM2) channel is a nonselective cation channel that mediates influx of Ca(2+) and Na(+) with relative permeability of PCa:PNa ≈0.6 in response to cellular oxidative stress. As angiogenesis and ischemic neovascularization are both significantly dependent on oxidant signaling, here we investigated the possible role of vascular endothelial growth factor...

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Source

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Identifiers

PMID: 25675998
DOI: 10.1161/ATVBAHA.114.304802
PMCID: PMC4396825

Genes

TRPM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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