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Article

CP-25 inhibits PGE2-induced angiogenesis by down-regulating EP4/AC/cAMP/PKA-mediated GRK2 translocation.

Clinical science (London, England : 1979) - 14 Feb 2020

Han Chen-Chen, Liu Qian, Zhang Yu, Li Yi-Fan, Cui Dong-Qian, Luo Ting-Ting, Zhang Yu-Wen, Wang Xin-Ming, Wang Chun, Ma Yang, Wei Wei

Abstract excerpt

G protein-coupled receptor kinase 2 (GRK2), a type of cytosolic enzyme, transiently translocates to the plasma membrane upon G protein-coupled receptors (GPCRs) activation, and it also binds to extracellular signal-regulated kinase (ERK) to inhibit the activation of ERK. GRK2 deficiency in endothelial cells (ECs) leads to increased pro-inflammatory signaling and promotes recruitment of leukocytes to activated...

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Identifiers

PMID: 31967309
DOI: 10.1042/CS20191032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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