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Article

Ancient DNA Study in Medieval Europeans Shows an Association Between HLA-DRB1*03 and Paratyphoid Fever.

Frontiers in immunology - 1 Jan 2021

Haller Magdalena, Bonczarowska Joanna H, Rieger Dirk, Lenz Tobias L, Nebel Almut, Krause-Kyora Ben

Abstract excerpt

Outbreaks of infectious diseases repeatedly affected medieval Europe, leaving behind a large number of dead often inhumed in mass graves. Human remains interred in two burial pits from 14th century CE Germany exhibited molecular evidence of Salmonella enterica Paratyphi C (S. Paratyphi C) infection. The pathogen is responsible for paratyphoid fever, which was likely the cause of death for the buried individuals....

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Identifiers

PMID: 34335597
DOI: 10.3389/fimmu.2021.691475
PMCID: PMC8320744

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