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Ancient DNA study provides clues to leprosy susceptibility in medieval Europe.

Genome biology - 16 Jan 2026

Romeyer-Dherbey Joanna H, Caliebe Amke, Ӧzer Onur, da Silva Nicolas Antonio, Mejía Nicolás Mendoza, Myburgh Daniel Anton, Fuchs Katharina, Pedersen Dorthe Dangvard, Boldsen Jesper, Larsen Lars Agersnap, Seeberg Lone, Søvsø Morten, Rieger Dirk, Prescher Andreas, Nebel Almut, Krause-Kyora Ben

Abstract excerpt

BACKGROUND: Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae) that reached an epidemic scale in the Middle Ages. Nowadays, the disease is absent in Europe and host genetic influences have been considered as a contributing factor to leprosy disappearance. In this study, we perform a case-control association analysis between multiple human leukocyte antigen (HLA) alleles and leprosy...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41540446
DOI: 10.1186/s13059-025-03925-8
PMCID: PMC12838506

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