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Article

Ten millennia of purifying selection on HLA-B27 reveals an ancient epidemic-scale burden of spondyloarthritis in West Eurasia.

Autoimmunity reviews - 1 Oct 2026

Zheng Ming

Abstract excerpt

HLA-B27 exemplifies an evolutionary trade-off between protection against infection and susceptibility to inflammatory disease. To investigate its long-term population history, this study examined three HLA-B27-tagging variants-rs116488202, rs4349859, and rs116666910-in present-day populations from UK biobank and 1000 Genomes Project, and in 15,836 ancient West Eurasian individuals. The estimated frequency of...

Read the complete abstract on PubMed

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Topics

Humans
HLA-B27 Antigen
Genome-Wide Association Study
Genetic Predisposition to Disease
Selection, Genetic
Spondylarthritis
Spondylitis, Ankylosing
Gene Frequency
Polymorphism, Single Nucleotide
Alleles
Epidemics

Source

Identifiers

PMID: 42442590
DOI: 10.1016/j.autrev.2026.104140

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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