Article
An Animal Model Further Uncovers the Role of Mutant BrafV600E during Papillary Thyroid Cancer Development.
The American journal of pathology - 1 Mar 2020
Koelsch Bernd, Theurer Sarah, Staniszewska Magdalena, Heupel Jacqueline, Koch Amelie, Mergener Svenja, Walk Franziska, Fischer Christine, Kutritz Andrea, Schmid Kurt W, Kindler-Röhrborn Andrea
Abstract excerpt
Papillary thyroid carcinomas (PTCs) account for 90% of human thyroid cancer cases, which represent 1% of all cancer cases. They are likely to develop from papillary thyroid microcarcinomas (PTMCs), found in up to 36% of healthy individuals, due to rare progression events (0.01%). Although the prognosis of PTCs is excellent, 5% to 10% of tumors display an unfavorable outcome. About 45% of PTCs exhibit activating...
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