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TCF7L2 Genetic Variants Do Not Influence Insulin Sensitivity or Secretion Indices in Autoantibody-Positive Individuals at Risk for Type 1 Diabetes.

Diabetes care - 1 Sept 2021

Redondo Maria J, Warnock Megan V, Libman Ingrid M, Bocchino Laura E, Cuthbertson David, Geyer Susan, Pugliese Alberto, Steck Andrea K, Evans-Molina Carmella, Becker Dorothy, Sosenko Jay M, Bacha Fida

Abstract excerpt

OBJECTIVE: We aimed to test whether type 2 diabetes (T2D)-associated TCF7L2 genetic variants affect insulin sensitivity or secretion in autoantibody-positive relatives at risk for type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: We studied autoantibody-positive TrialNet Pathway to Prevention study participants (N = 1,061) (mean age 16.3 years) with TCF7L2 single nucleotide polymorphism (SNP) information and...

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Source

Open in PubMed Open full text

Identifiers

PMID: 34326068
DOI: 10.2337/dc21-0531
PMCID: PMC8740915

Genes

TCF7L2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TCF7L2 Genetic Variants Do Not Influence Insulin Sensitivity or Secretion Indices in Autoantibody-Positive Individuals at Risk for Type 1 Diabetes.PMID 34326068Read ↗

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