Article
Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity.
Diabetes - 1 Dec 2014
Scott Robert A, Fall Tove, Pasko Dorota, Barker Adam, Sharp Stephen J, Arriola Larraitz, Balkau Beverley, Barricarte Aurelio, Barroso Inês, Boeing Heiner, Clavel-Chapelon Françoise, Crowe Francesca L, Dekker Jacqueline M, Fagherazzi Guy, Ferrannini Ele, Forouhi Nita G, Franks Paul W, Gavrila Diana, Giedraitis Vilmantas, Grioni Sara, Groop Leif C, Kaaks Rudolf, Key Timothy J, Kühn Tilman, Lotta Luca A, Nilsson Peter M, Overvad Kim, Palli Domenico, Panico Salvatore, Quirós J Ramón, Rolandsson Olov, Roswall Nina, Sacerdote Carlotta, Sala Núria, Sánchez María-José, Schulze Matthias B, Siddiq Afshan, Slimani Nadia, Sluijs Ivonne, Spijkerman Annemieke Mw, Tjonneland Anne, Tumino Rosario, van der A Daphne L, Yaghootkar Hanieh, McCarthy Mark I, Semple Robert K, Riboli Elio, Walker Mark, Ingelsson Erik, Frayling Tim M, Savage David B, Langenberg Claudia, Wareham Nicholas J
Abstract excerpt
We aimed to validate genetic variants as instruments for insulin resistance and secretion, to characterize their association with intermediate phenotypes, and to investigate their role in type 2 diabetes (T2D) risk among normal-weight, overweight, and obese individuals. We investigated the association of genetic scores with euglycemic-hyperinsulinemic clamp- and oral glucose tolerance test-based measures of...
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