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Article

A comprehensive map of single-base polymorphisms in the hypervariable LPA kringle IV type 2 copy number variation region

12 Nov 2018

Abstract excerpt

Lipoprotein (a) [Lp(a)] concentrations are among the strongest genetic risk factors for cardiovascular disease and present pronounced interethnic and interindividual differences. Approximately 90#x0025; of Lp(a) variance is controlled by the LPA gene, which contains a 5.6-kb-large copy number variation [kringle IV type 2 (KIV-2) repeat] that generates >40 protein isoforms. Variants within the KIV-2 region are not...

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PMID: 30413653
DOI: 10.1194/jlr.m090381

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A comprehensive map of single-base polymorphisms in the hypervariable LPA kringle IV type 2 copy number variation regionPMID 30413653Read ↗

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