Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis.

doi:10.1016/S2213-8587(17)30088-8

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Article

Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis.

The lancet. Diabetes & endocrinology - 1 Jul 2017

Saleheen Danish, Haycock Philip C, Zhao Wei, Rasheed Asif, Taleb Adam, Imran Atif, Abbas Shahid, Majeed Faisal, Akhtar Saba, Qamar Nadeem, Zaman Khan Shah, Yaqoob Zia, Saghir Tahir, Rizvi Syed Nadeem Hasan, Memon Anis, Mallick Nadeem Hayyat, Ishaq Mohammad, Rasheed Syed Zahed, Memon Fazal-Ur-Rehman, Mahmood Khalid, Ahmed Naveeduddin, Frossard Philippe, Tsimikas Sotirios, Witztum Joseph L, Marcovina Santica, Sandhu Manjinder, Rader Daniel J, Danesh John

Abstract excerpt

BACKGROUND: The lipoprotein(a) pathway is a causal factor in coronary heart disease. We used a genetic approach to distinguish the relevance of two distinct components of this pathway, apolipoprotein(a) isoform size and circulating lipoprotein(a) concentration, to coronary heart disease. METHODS: In this mendelian randomisation study, we measured lipoprotein(a) concentration and determined apolipoprotein(a)...

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PMID: 28408323
DOI: 10.1016/S2213-8587(17)30088-8
PMCID: PMC5483508

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