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Article

LPA Kringle IV Type-2 Genetic Variants Are Associated With Apolipoprotein (a) Size, Hypertension, and Nonfasting Glucose Levels.

Journal of the American Heart Association - 7 Jul 2026

Li Yihao, Kronenberg Florian, Coassin Stefan, Vardarajan Badri, Reyes-Soffer Gissette

Abstract excerpt

BACKGROUND: High plasma lipoprotein (a) (Lp[a]) levels, largely regulated by variation in the LPA gene, are a causal risk factor for atherosclerotic cardiovascular disease. LPA Kringle IV type 2 (KIV-2) copy number (CN) inversely associates with Lp(a) levels, with Black and Hispanic individuals exhibiting higher Lp(a) levels than White individuals. These populations are underrepresented in genetic studies. We...

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Identifiers

PMID: 42333705
DOI: 10.1161/JAHA.125.043246
PMCID: PMC13477386

Genes

LPA

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LPA Kringle IV Type-2 Genetic Variants Are Associated With Apolipoprotein (a) Size, Hypertension, and Nonfasting Glucose Levels.PMID 42333705Read ↗

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