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Cellular senescence or stemness: hypoxia flips the coin

29 Jul 2021

Abstract excerpt

Cellular senescence is a complex physiological state whose main feature is proliferative arrest. Cellular senescence can be considered the reverse of cell immortalization and continuous tumor growth. However, cellular senescence has many physiological functions beyond being a putative tumor suppressive trait. It remains unknown whether low levels of oxygen or hypoxia, which is a feature of every tissue in the...

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PMID: 34325734
DOI: 10.1186/s13046-021-02035-0

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