Senescence induction; a possible cancer therapy

Abstract excerpt

Cellular immortalization is a crucial step during the development of human cancer. Primary mammalian cells reach replicative exhaustion after several passages in vitro, a process called replicative senescence. During such a state of permanent growth arrest, senescent cells are refractory to physiological proliferation stimuli: they have altered cell morphology and gene expression patterns, although they remain...

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• Share to Advanced biosensing and bioanalysis techniques
• Share to Epigenetics and DNA Methylation
• Share to Telomeres, Telomerase, and Senescence