Article
Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies.
Psychopharmacology - 1 Jul 1997
Crawley J N, Belknap J K, Collins A, Crabbe J C, Frankel W, Henderson N, Hitzemann R J, Maxson S C, Miner L L, Silva A J, Wehner J M, Wynshaw-Boris A, Paylor R
Abstract excerpt
Choosing the best genetic strains of mice for developing a new knockout or transgenic mouse requires extensive knowledge of the endogenous traits of inbred strains. Background genes from the parental strains may interact with the mutated gene, in a manner which could severely compromise the interpretation of the mutant phenotype. The present overview summarizes the literature on a wide variety of behavioral...
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