Article
The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite.
Nature communications - 27 Jul 2021
Zhang Min, Wang Chengqi, Oberstaller Jenna, Thomas Phaedra, Otto Thomas D, Casandra Debora, Boyapalle Sandhya, Adapa Swamy R, Xu Shulin, Button-Simons Katrina, Mayho Matthew, Rayner Julian C, Ferdig Michael T, Jiang Rays H Y, Adams John H
Abstract excerpt
The emergence and spread of Plasmodium falciparum parasites resistant to front-line antimalarial artemisinin-combination therapies (ACT) threatens to erase the considerable gains against the disease of the last decade. Here, we develop a large-scale phenotypic screening pipeline and use it to carry out a large-scale forward-genetic phenotype screen in P. falciparum to identify genes allowing parasites to survive...
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