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A mutagenesis screen for essential plastid biogenesis genes in human malaria parasites

6 Feb 2019

Abstract excerpt

Endosymbiosis has driven major molecular and cellular innovations. Plasmodium spp. parasites that cause malaria contain an essential, non-photosynthetic plastid-the apicoplast-which originated from a secondary (eukaryote-eukaryote) endosymbiosis. To discover organellar pathways with evolutionary and biomedical significance, we performed a mutagenesis screen for essential genes required for apicoplast biogenesis...

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PMID: 30726238
DOI: 10.1371/journal.pbio.3000136

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