Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-Scale Identification of Essential Metabolic Processes for Targeting the Plasmodium Liver Stage.

Cell - 14 Nov 2019

Stanway Rebecca R, Bushell Ellen, Chiappino-Pepe Anush, Roques Magali, Sanderson Theo, Franke-Fayard Blandine, Caldelari Reto, Golomingi Murielle, Nyonda Mary, Pandey Vikash, Schwach Frank, Chevalley Séverine, Ramesar Jai, Metcalf Tom, Herd Colin, Burda Paul-Christian, Rayner Julian C, Soldati-Favre Dominique, Janse Chris J, Hatzimanikatis Vassily, Billker Oliver, Heussler Volker T

Abstract excerpt

Plasmodium gene functions in mosquito and liver stages remain poorly characterized due to limitations in the throughput of phenotyping at these stages. To fill this gap, we followed more than 1,300 barcoded P. berghei mutants through the life cycle. We discover 461 genes required for efficient parasite transmission to mosquitoes through the liver stage and back into the bloodstream of mice. We analyze the screen...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Culicidae
Share to Fatty Acid Synthases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockout Techniques

Share to Genome, Protozoan

Share to Life Cycle Stages

Share to Parasites

Share to Plasmodium berghei

Share to Ploidies

Source

Open in PubMed Open full text

Identifiers

PMID: 31730853
DOI: 10.1016/j.cell.2019.10.030
PMCID: PMC6904910

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-Scale Identification of Essential Metabolic Processes for Targeting the Plasmodium Liver Stage.PMID 31730853Read ↗

Host metabolic pathways essential for malaria and related hemoparasites in the infection of nucleated cellsSemantic proximity Read ↗

Comparative analyses of parasites with a comprehensive database of genome-scale metabolic modelsSemantic proximity Read ↗

Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysisSemantic proximity Read ↗

Functional and Computational Genomics Reveal Unprecedented Flexibility in Stage-Specific Toxoplasma Metabolism.Semantic proximity Read ↗

Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasitesSemantic proximity Read ↗

Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistanceSemantic proximity Read ↗

Beyond immunity: a transcriptomic landscape of Plasmodium’s modulation of mosquito metabolic pathwaysSemantic proximity Read ↗

Novel <i>Plasmodium falciparum</i> metabolic network reconstruction identifies shifts associated with clinical antimalarial resistanceSemantic proximity Read ↗

Malaria Parasite Metabolic Pathways (MPMP) Upgraded with Targeted Chemical CompoundsSemantic proximity Read ↗

Composition and stage dynamics of mitochondrial complexes in Plasmodium falciparumSemantic proximity Read ↗

Genome-scale metabolic models highlight stage-specific differences in essential metabolic pathways in Trypanosoma cruziSemantic proximity Read ↗

Dissecting Leishmania infantum Energy Metabolism - A Systems PerspectiveSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.