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Article

Gαq activation modulates autophagy by promoting mTORC1 signaling.

Nature communications - 27 Jul 2021

Cabezudo Sofía, Sanz-Flores Maria, Caballero Alvaro, Tasset Inmaculada, Rebollo Elena, Diaz Antonio, Aragay Anna M, Cuervo Ana María, Mayor Federico, Ribas Catalina

Abstract excerpt

The mTORC1 node plays a major role in autophagy modulation. We report a role of the ubiquitous Gαq subunit, a known transducer of plasma membrane G protein-coupled receptors signaling, as a core modulator of mTORC1 and autophagy. Cells lacking Gαq/11 display higher basal autophagy, enhanced autophagy induction upon different types of nutrient stress along with a decreased mTORC1 activation status. They are also...

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Identifiers

PMID: 34315875
DOI: 10.1038/s41467-021-24811-4
PMCID: PMC8316552

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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