Article
Spatial coupling of mTOR and autophagy augments secretory phenotypes.
Science (New York, N.Y.) - 20 May 2011
Narita Masako, Young Andrew R J, Arakawa Satoko, Samarajiwa Shamith A, Nakashima Takayuki, Yoshida Sei, Hong Sungki, Berry Lorraine S, Reichelt Stefanie, Ferreira Manuela, Tavaré Simon, Inoki Ken, Shimizu Shigeomi, Narita Masashi
Abstract excerpt
Protein synthesis and autophagic degradation are regulated in an opposite manner by mammalian target of rapamycin (mTOR), whereas under certain conditions it would be beneficial if they occurred in unison to handle rapid protein turnover. We observed a distinct cellular compartment at the trans side of the Golgi apparatus, the TOR-autophagy spatial coupling compartment (TASCC), where (auto)lysosomes and mTOR...
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