Article
HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity.
Cell death & disease - 26 Jul 2021
Luo Wenwei, Li Jingyan, Li Ziqing, Lin Tong, Zhang Lili, Yang Wanqi, Mai Yanqi, Liu Ruiming, Chen Meiting, Dai Chunmei, Yang Hanwei, Lu Jing, Li Hong, Guan Guimei, Huang Min, Liu Peiqing, Li Zhuoming
Abstract excerpt
Heme oxygenase-1 (HO-1) has attracted accumulating attention for its antioxidant enzymatic activity. However, the exact regulatory role of its non-enzymatic activity in the cardiovascular system remains unaddressed. Here, we show that HO-1 was accumulated in the nuclei of stress-induced senescent endothelial cells, and conferred protection against endothelial senescence independent of its enzymatic activity....
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