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Article

Transcriptional and phenotypic changes in aorta and aortic valve with aging and MnSOD deficiency in mice.

American journal of physiology. Heart and circulatory physiology - 15 Nov 2013

Roos Carolyn M, Hagler Michael, Zhang Bin, Oehler Elise A, Arghami Arman, Miller Jordan D

Abstract excerpt

The purpose of this study was to characterize changes in antioxidant and age-related gene expression in aorta and aortic valve with aging, and test the hypothesis that increased mitochondrial oxidative stress accelerates age-related endothelial and aortic valve dysfunction. Wild-type (MnSOD(+/+)) and manganese SOD heterozygous haploinsufficient (MnSOD(+/-)) mice were studied at 3 and 18 mo of age. In aorta from...

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Identifiers

PMID: 23997094
DOI: 10.1152/ajpheart.00735.2012
PMCID: PMC3840262

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SIRT1
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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